研究员/教授

李华芳

     博士, 主任医师,博导、研究组长、学科带头人

     学士:1984年-1990年(上海医科大学

     硕士:1992年-1995年(上海医科大学

     博士:1997年-2000年(上海医科大学

     Email: lhlh_5@163.com

 

 

个人介绍:

上海市精神卫生中心国家药物临床试验机构执行主任,临床研究中心副主任。长期从事精神医学医教研一线工作。曾于2003年和2013年分别在Indianapolis Purdue University Indianapolis和North Shore Jewish Health System (Zucker Hillside Hospital)做高级访问学者。CDE咨询专家,国际神经精神药理学会中国学会(ChCNP)委员,中国精神科医师协会-精神药理和药物治疗工作委员会委员,上海市药理学会临床药理专业委员会委员,上海市药理学会药物临床试验专业委员会委员,上海市药学会临床研究专业委员会委员,上海交通大学医学院临床研究中心专家委员会,《上海精神医学》《中国新药与临床》《中国临床药学杂志》等杂志编委,美国临床研究协会(Association of Clinical Research Professionals, ACRP)和临床试验专家协会(academy of physicians in clinical research professionalsAPCR)的会员并获PI认证(ACRP-CPI®)。发起成立中国“精神药物临床试验协作网”,任首任工作组组长。致力于整体提升精神药物临床研究能力和质量的建设工作,搭建符合国际规范并服务于国内外创新精神药物临床研发的GCP技术平台。发表文章约230篇,其中SCI 58篇,参编专著12部,主编2部。

 

研究方向:

精神药物新药临床研发和精神障碍个体化医疗

 

代表性项目:

作为课题负责人和上海卫生系统优秀学科带头人,主持十一五、十二五和十三五“重大新药创制”科技重大专项课题“精神药物新药临床评价研究技术平台”、上海市重点医学项目、交通大学医学院高峰高原多中心试验等重要科研课题10余项。

 

代表性论文:

  1. Yan Li, Fan Zhang, Yanmei Xu, Joice Hu, and Huafang Li[通讯] Pharmacokinetics, Safety, and Tolerability of Lamotrigine Chewable/Dispersible Tablet Following Repeat-Dose Administration in Healthy Chinese Volunteers. Clinical Pharmacology in Drug Development 2018; 00(0) 17

  2. Duan Zeng,Shen He,Shunying Yu,Guanjun Li,Changlin Ma,Yi Wen,Yifeng Shen,Yimin Yu,Huafang Li【通讯】. Analysis of the association of MIR124-1 and its target gene RGS4 polymorphisms with major depressive disorder and antidepressant response.  Neuropsychiatric Disease and Treatment 2018;14:715–723

  3. Li H, Shen Y, Wang G, Shi J, Ma C, Xie S, Zhang H, Wang X, Li K, Xu X, Gu N【通讯】. A 6-week, multicenter, double-blind, double-dummy, chlorpromazine-controlled non-inferiorityrandomized phase iiitrial to evaluate the efficacy and safety of quetiapine fumarate (SEROQUEL) extended-release (XR) in the treatment of patients with schizophrenia and acute episodes.Psychiatry Research. 2018;259:117-124.

  4. Shen He, Xiaohua Liu, Kaida Jiang, Daihui Peng, Wu Hong, Yiru Fang,Yiping Qian, Shunying Yu, Huafang Li【通讯】Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder Journal of Psychiatric Research 2016;78:65-71

  5. W.Yu, X. Sun, Y Li,K.Wang, H.Li【通讯】. Population pharmacokinetics of lithium carbonate in young male healthy Chinese volunteers. Pharmacopsychiatry. 2016 Sep;49(5):177-181

  6. Huafang Li,Yan Li,Yu Feng,Jianmin Zhuo,Ibrahim Turkoz,Maju Mathews,Wilson Tan. Impact of time of initiation of once-monthly paliperidone palmitate in hospitalized Asian patients with acute exacerbation of schizophrenia: a post hoc analysis from the PREVAIL study. Neuropsychiatric Disease and Treatment 2018:14 1107–1117.

  7. Yi-Min Yu, MD,* Ke-Run Gao, MD, PhD,* Hao Yu, PhD,†Yi-Feng Shen, MD, PhD,* and Hua-Fang Li, MD, PhD*【通讯】. Efficacy and Safety of Agomelatine vs Paroxetine Hydrochloride in Chinese Han Patients with Major Depressive Disorder A Multicentre, Double-Blind, Noninferiority, Randomized Controlled Trial. J Clin Psychopharmacol 2018;38: 226233.

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