近期论文

Functional connectome organization predicts conversion to psychosis in clinical high-risk youth from the SHARP program.(IF=11.64)

 2018 Nov 8. doi: 10.1038/s41380-018-0288-x. [Epub ahead of print]

Collin G1,2,3Seidman LJ4Keshavan MS4Stone WS4Qi Z4,5Zhang T6Tang Y6Li H7Anteraper SA8,9Niznikiewicz MA10McCarley RW10Shenton ME11,12,13Wang J14Whitfield-Gabrieli S8,15.

Author information

1.Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. gcollin@bidmc.harvard.edu.
2.McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. gcollin@bidmc.harvard.edu.
3.Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. gcollin@bidmc.harvard.edu.
4.Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
5.Department of Linguistics and Cognitive Science, University of Delaware, Newark, DE, USA.
6.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
7.Department of Psychology, Florida A&M University, Tallahassee, FL, USA.
8.McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
9.Alan and Lorraine Bressler Clinical and Research Program for Autism Spectrum Disorder, Massachusetts General Hospital, Boston, MA, USA.
10.Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Brockton, MA, USA.
11.Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
12.Research and Development, VA Boston Healthcare System, Brockton Division, Brockton, MA, USA.
13.Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
14.Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jijunwang27@163.com.
15.Poitras Center for Affective Disorders, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
 

Abstract

The emergence of prodromal symptoms of schizophrenia and their evolution into overt psychosis may stem from an aberrant functional reorganization of the brain during adolescence. To examine whether abnormalities in connectome organization precede psychosis onset, we performed a functional connectome analysis in a large cohort of medication-naive youth at risk for psychosis from the Shanghai At Risk for Psychosis (SHARP) study. The SHARP program is a longitudinal study of adolescents and young adults at Clinical High Risk (CHR) for psychosis, conducted at the Shanghai Mental Health Center in collaboration with neuroimaging laboratories at Harvard and MIT. Our study involved a total of 251 subjects, including 158 CHRs and 93 age-, sex-, and education-matched healthy controls. During 1-year follow-up, 23 CHRs developed psychosis. CHRs who would go on to develop psychosis were found to show abnormal modular connectome organization at baseline, while CHR non-converters did not. In all CHRs, abnormal modular connectome organization at baseline was associated with a threefold conversion rate. A region-specific analysis showed that brain regions implicated in early-course schizophrenia, including superior temporal gyrus and anterior cingulate cortex, were most abnormal in terms of modular assignment. Our results show that functional changes in brain network organization precede the onset of psychosis and may drive psychosis development in at-risk youth.

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