近期论文

Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group.(IF=13.391)

 2018 May 1;175(5):453-462. doi: 10.1176/appi.ajp.2017.17050485. Epub 2017 Dec 15.

Boedhoe PSW1Schmaal L1Abe Y1Alonso P1Ameis SH1Anticevic A1Arnold PD1Batistuzzo MC1Benedetti F1Beucke JC1Bollettini I1Bose A1Brem S1Calvo A1Calvo R1Cheng Y1Cho KIK1Ciullo V1Dallaspezia S1Denys D1Feusner JD1Fitzgerald KD1Fouche JP1Fridgeirsson EA1Gruner P1Hanna GL1Hibar DP1Hoexter MQ1Hu H1Huyser C1Jahanshad N1James A1Kathmann N1Kaufmann C1Koch K1Kwon JS1Lazaro L1Lochner C1Marsh R1Martínez-Zalacaín I1Mataix-Cols D1Menchón JM1Minuzzi L1Morer A1Nakamae T1Nakao T1Narayanaswamy JC1Nishida S1Nurmi E1O'Neill J1Piacentini J1Piras F1Piras F1Reddy YCJ1Reess TJ1Sakai Y1Sato JR1Simpson HB1Soreni N1Soriano-Mas C1Spalletta G1Stevens MC1Szeszko PR1Tolin DF1van Wingen GA1Venkatasubramanian G1Walitza S1Wang Z1Yun JY1ENIGMA-OCD WorkingGroup1Thompson PM1Stein DJ1van den Heuvel OA1ENIGMA OCD Working Group.

 

Abstract

OBJECTIVE:

Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken.

METHOD:

T1-weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume.

RESULTS:

In adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortex and a thinner inferior parietal cortex. Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showed significant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from -0.10 to -0.33.

CONCLUSIONS:

The parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.

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